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Compatible with a variety of user-friendly software packages and camera systems, the Leica DM4000 B is the ideal microscope for life science research and clinical applications. The DM4000 B with Intelligent Automation features a coded 6x or 7x nosepiece, manual z-focus, and fully automated transmitted-and fluorescence axis. All microscope settings are saved and displayed to provide reproducible results. Leica Microsystems’ Contrast Manager supports the transmitted light (brightfield, darkfield, phase contrast and polarization contrast) and fluorescence contrast methods and allows the user to switch from one contrast method to another with one push of a button. Based on the selected objective and contrast method, all necessary adjustments are automatically done.